HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 7-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Ethyl 2-isonicotinoylthiophene-3-carboxylate | HCID 86683117 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-one | HCID 86683118 | 85.1% |
Reaction Steps
The mixture of ethyl 2-isonicotinoylthiophene-3-carboxylate (200 mg, 0.77 mmol) from example 2.2 in NH2NH2.H2O (2 mL) and EtOH (10 mL) was stirred at room temperature for 30 min. The mixture was filtered and the solid dried to obtain the title compound (150 mg, 85.1% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273068B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-1486e61f12834859b396a2cbe561b3cc |
| Source note | uspto-grants-2016_03 |