HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920907Generated: October 30, 2026
Potassium Carbonate → HCID 71557602, compound
https://huagongshe.com/reaction/920907
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Reactant | HCID 86683119 | HCID 86683119 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 71557602 | HCID 71557602 | 70.9% |
Reaction Steps
3-Bromo-5-[2-(quinolin-2-yl)ethyl]thieno[2,3-d]pyridazin-4(5H)-one (130 mg, 0.33 mmol), pyridine-4-ylboronic acid (45.7 mg, 0.37 mmol), Pd(dppf)Cl2 (15 mg) and K2CO3 (93 mg, 0.67 mmol) were dissolved in dioxane/H2O (3/1, 2.8 mL). The mixture was stirred in nitrogen atmosphere at 120° C. for 1 h in a microwave tube. The solution was concentrated and purified by TLC (DCM/MeOH=10/1) and recrystallized from MeOH to give the title product (90 mg, 69.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09273068B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-46a6a7d5bb934c50a162864c88cd9be9 |
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| Source note | uspto-grants-2016_03 |
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