2-(2-Hydroxyethyl)pyridine → HCID 86683122, compound

HRID 920910Notes

Reaction equation

HRID 920910 reaction equation
[Br:1][C:2]1[C:10]2[C:9](=[O:11])[NH:8][N:7]=[C:6]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[C:5]=2[S:4][CH:3]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH2:24][CH2:25]O>>[Br:1][C:2]1[C:10]2[C:9](=[O:11])[N:8]([CH2:25][CH2:24][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=3)[N:7]=[C:6]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[C:5]=2[S:4][CH:3]=1

Participants

3

Reactant 2

HCID 76752-(2-Hydroxyethyl)pyridineHCID 86683123HCID 86683123, compound

Product 1

HCID 86683122HCID 86683122, compoundYield 70%

Procedure

The title compound was prepared in analogy to the process described in Example 3.4 starting from 3-bromo-7-pyridin-4-yl-5H-thieno[2,3-d]pyridazin-4-one and 2-pyridin-2-yl-ethanol. Yield: 70%.

Sources & evidence

ORD record
ord-9e1cacb7ba384d3da4096536f367c93c
Source dataset
uspto-grants-2016_03
Patent number
US09273068B2

Reaction notes

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