(Pyridin-4-yl)boronic acid → HCID 71557603, compound

HRID 920911Notes

Reaction equation

HRID 920911 reaction equation
Br[C:2]1[C:10]2[C:9](=[O:11])[N:8]([CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[N:7]=[C:6]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)[C:5]=2[S:4][CH:3]=1.[N:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1>>[N:26]1[CH:31]=[CH:30][C:29]([C:2]2[C:10]3[C:9](=[O:11])[N:8]([CH2:12][CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=4)[N:7]=[C:6]([C:20]4[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=4)[C:5]=3[S:4][CH:3]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 86683122HCID 86683122, compound

Product 1

HCID 71557603HCID 71557603, compoundYield 75.2%

Procedure

The title compound was prepared in analogy to the process described in Example 3.5 starting from 3-bromo-7-pyridin-4-yl-5-[2-(pyridin-2-yl)ethyl]thieno[2,3-d]pyridazin-4(5H)-one and pyridine-4-ylboronic acid. Yield: 75.2%.

Sources & evidence

ORD record
ord-3266c58514c24521a2cf6db24cad8fb2
Source dataset
uspto-grants-2016_03
Patent number
US09273068B2

Reaction notes

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