HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920912Generated: November 1, 2026
Potassium Carbonate → HCID 71557604, compound
https://huagongshe.com/reaction/920912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | HCID 86683119 | HCID 86683119 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 71557604 | HCID 71557604 | — |
Reaction Steps
3-Bromo-5-[2-(quinolin-2-yl)ethyl]thieno[2,3-d]pyridazin-4(5H)-one Example 3.4 (100 mg, 0.26 mmol), 4-(trifluoromethyl)phenylboronic acid (0.26 mmol), Pd(dppf)Cl2 (12.7 mg) and K2CO3 (72 mg, 0.527 mmol) were dissolved in dioxane/H2O (3/1, 2.8 mL). The mixture was stirred at 110° C. for 0.5 h in a microwave tube. The solution was concentrated and purified by prep-TLC to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273068B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-64ae4852bb174072ace9011a9e2fef7f |
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| Source note | uspto-grants-2016_03 |
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