HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920913Generated: October 28, 2026
Potassium Carbonate → HCID 86683124, compound
https://huagongshe.com/reaction/920913
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Reactant | HCID 86683125 | HCID 86683125 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86683124 | HCID 86683124 | 68.6% |
Reaction Steps
3-Bromo-5-(2-(6-fluoroquinolin-2-yl)ethyl)thieno[2,3-d]pyridazin-4(5H)-one (66 mg, 0.163 mmol) was dissolved in dioxane (2.1 mL) and H2O (0.7 mL), pyridin-4-yl boronic acid (20.07 mg, 0.163 mmol), K2CO3 (45.1 mg, 0.327 mmol) and Pd(dppf)Cl2 (7.23 mg, 9.80 μmol) were each added sequentially to the suspension. The suspension was heated in a microwave tube at about 110° C. for 1 h. The crude product was purified by TLC (EA) to give the title compound (45 mg, yield: 68.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09273068B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-b8279ae550984501938c04b51ad718e8 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
