Cesium carbonate → HCID 86683132, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-bromo-5-(2-(7-fluoroimidazo[1,2-a]pyridin-2-yl)ethyl)thieno[2,3-d]pyridazin-4(5H)-one (80 mg, 0.203 mmol), pyridin-4-ylboronic acid (37.5 mg, 0.305 mmol), PdCl2(dppf)-CH2Cl2 adduct (16.61 mg, 0.020 mmol) and Cs2CO3 (133 mg, 0.407 mmol) in 1,4-dioxane (3 mL) and water(1.5 mL) was heated under microwave at about 110° C. for about 15 min. The mixture was concentrated and was chromatographed on the ISCO Combiflash system using a 40 g Silicycle SiliaSep Silica gel column C-18 column using the following gradient: A: Water (0.1% NH4HCO3); B: Methanol; 30% B to 80% B over 20 min (15 mg, 18.8%).

Provenance & Evidence