HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920921Generated: October 30, 2026
Water → 8-(Pyridin-4-yl)-2-[2-(quinolin-2-yl)ethyl]phthalazin-1(2H)-one
https://huagongshe.com/reaction/920921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Reactant | 8-Chloro-2-(2-(quinolin-2-YL)ethyl)phthalazin-1(2H)-one | HCID 71743639 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 8-(Pyridin-4-yl)-2-[2-(quinolin-2-yl)ethyl]phthalazin-1(2H)-one | HCID 86683133 | — |
Reaction Steps
A reaction tube was charged with pyridin-4-ylboronic acid (0.223 mmol), K2CO3 (61.7 mg, 0.447 mmol) under a dry nitrogen atmosphere. A solution of 8-chloro-2-(2-quinolin-2-yl-ethyl)-2H-phthalazin-1-one (50 mg, 0.186 mmol) in 1,4-dioxane (5 mL) along with PdCl2(dppf) (5.45 mg, 7.45 μmol) was added. After addition of water (1 mL), the resulting mixture was heated at 100° C. overnight. After removal of the solvent under reduced pressure, the title compound was obtained as a crude product. It was purified by Prep-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273068B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-61067d586e204fb7a77d47c19e50a546 |
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| Source note | uspto-grants-2016_03 |
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