Morpholine → HCID 86683143, compound

HRID 920930Notes

Reaction equation

HRID 920930 reaction equation
Br[C:2]1[C:6]2[C:7](=[O:11])[NH:8][CH:9]=[CH:10][C:5]=2[S:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[O:15]1[CH2:16][CH2:17][N:12]([C:2]2[C:6]3[C:7](=[O:11])[NH:8][CH:9]=[CH:10][C:5]=3[S:4][CH:3]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 184507963-Bromothieno[3,2-c]pyridin-4(5H)-one

Product 1

HCID 86683143HCID 86683143, compoundYield 42.7%

Procedure

3-Bromothieno[3,2-c]pyridin-4(5H)-one from Example 202.3 (411 mg, 1.786 mmol) and morpholine 81501 mg, 17.23 mmol) were stirred in a microwave for 3 h at 220° C. The mixture was poured onto water and extracted with DCM. The organic phase was concentrated and the residue was recrystallized from EA to give 180 mg (yield: 42.6%) of the title compound.

Workup

  1. additionThe mixture was poured onto water
  2. extractionextracted with DCM
  3. concentrationThe organic phase was concentrated
  4. customthe residue was recrystallized from EA

Sources & evidence

ORD record
ord-7c7cf88901ce4d718efbd8decd9bb8f8
Source dataset
uspto-grants-2016_03
Patent number
US09273068B2

Reaction notes

Loading…