HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920934Generated: October 31, 2026
Water → (E)-8-(pyridin-4-yl)-2-(2-(quinolin-2-yl)vinyl)isoquinolin-1(2H)-one
https://huagongshe.com/reaction/920934
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | (E)-2-(2-bromovinyl)quinoline | HCID 10421517 | — |
| Reactant | 8-(Pyridin-4-yl)isoquinolin-1(2H)-one | HCID 86683148 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (E)-8-(pyridin-4-yl)-2-(2-(quinolin-2-yl)vinyl)isoquinolin-1(2H)-one | HCID 86683149 | 40% |
Reaction Steps
8-(Pyridin-4-yl)isoquinolin-1(2H)-one (40 mg, 0.180 mmol) and (E)-2-(2-bromovinyl)quinoline (50.6 mg, 0.216 mmol) were dissolved in 2 mL of DMF under argon. The reaction mixture was stirred for 10 h at 115° C. Then, water and EA were added. The organic phase was washed with water and brine, dried (MgSO4) and concentrated. The crude product was purified by chromatography (CombiFlash, normal phase, gradient elution, using 3-5% DCM in methanol) to yield the title compound as yellow solid (27 mg, 40.0%). LCMS: 376.1; Rt=1.497.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273068B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-19c5bff4ea0d4e87810c584cba59c5a2 |
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| Source note | uspto-grants-2016_03 |
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