(Pyridin-4-yl)boronic acid → 7-(Pyridin-4-yl)-5-[2-(quinolin-2-yl)ethyl]furo[3,2-c]pyridin-4(5H)-one

HRID 920937Notes

Reaction equation

HRID 920937 reaction equation
Br[C:2]1[C:3]2[O:23][CH:22]=[CH:21][C:4]=2[C:5](=[O:20])[N:6]([CH2:8][CH2:9][C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH:7]=1.[N:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1>>[N:24]1[CH:29]=[CH:28][C:27]([C:2]2[C:3]3[O:23][CH:22]=[CH:21][C:4]=3[C:5](=[O:20])[N:6]([CH2:8][CH2:9][C:10]3[CH:19]=[CH:18][C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[N:11]=3)[CH:7]=2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 866831507-Bromo-5-(2-(quinolin-2-yl)ethyl)furo[3,2-c]pyridin-4(5H)-one

Product 1

HCID 866831517-(Pyridin-4-yl)-5-[2-(quinolin-2-yl)ethyl]furo[3,2-c]pyridin-4(5H)-one

Procedure

165.2 but using 7-bromo-5-(2-(quinolin-2-yl)ethyl)furo[3,2-c]pyridin-4(5H)-one (61.7 mg, 0.167 mmol) and pyridin-4-ylboronic acid (22.82 mg, 0.167 mmol mmol). The title compound was obtained as yellowish solid (yield: 22 mg, 35.8.9%).

Sources & evidence

ORD record
ord-7f920bc74d824a06b9deb64160d6f5fa
Source dataset
uspto-grants-2016_03
Patent number
US09273068B2

Reaction notes

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