HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetohydrazide → HCID 140606545, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetohydrazide | HCID 14039 | — |
| Reactant | 3-Pyridinecarboxylic acid, 4-chloro-2-formyl-, ethyl ester | HCID 86683157 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 140606545 | HCID 140606545 | 73.6% |
Reaction Steps
To 2.1 g (9.83 mmol) of ethyl 4-chloro-2-formylnicotinate in 60 mL of ethanol was added 0.874 g (11.80 mmol) of acetohydrazide at room temperature. Then, the reaction mixture was heated under reflux for 2 h. The reaction mixture was extracted with water/DCM. The organic phase was washed with brine, dried, filtrated and concentrated to give 1.95 g (73.6%) of the title compound as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273068B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-d101b573c95e46b892a69e7c707ecee8 |
| Source note | uspto-grants-2016_03 |