Ethylamine → HCID 68011884, compound

HRID 920958Notes

Reaction equation

HRID 920958 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]2=[C:5]([C:12]([O-:14])=O)[N:4]=1.[CH2:17]([NH2:19])[CH3:18]>>[CH2:17]([NH:19][C:12]([C:5]1[N:4]=[C:3]([C:2]([F:1])([F:16])[F:15])[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]=12)=[O:14])[CH3:18]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 86685642HCID 86685642, compound

Product 1

HCID 68011884HCID 68011884, compound

Conditions

Temperature
50 °C

Procedure

3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylate 3b (1 g, 4 mmol) was dissolved in 40 mL of ethylamine solution (60%). After stirring at 50° C. for 12 hours, the reaction mixture was concentrated under reduced pressure to obtain the crude N-ethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide 7a (1.15 g) as a white solid. The product was used directly in the next reaction without purification.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-14f7b98c697c440f8f7648d4d464b23e
Source dataset
uspto-grants-2016_03
Patent number
US09273052B2

Reaction notes

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