HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Tert-butyl-2-chloropyridine-3-carbonitrile → 6-tert-Butyl-2-(3,3-dimethylbut-1-ynyl)-5-methylnicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Tert-butyl-2-chloropyridine-3-carbonitrile | HCID 53278876 | — |
| Reactant | 6-Tert-butyl-2-chloro-5-methylnicotinonitrile | HCID 86680262 | — |
| Product | 6-tert-Butyl-2-(3,3-dimethylbut-1-ynyl)-5-methylnicotinonitrile | HCID 67995432 | — |
Reaction Steps
Procedure analogous to 31, using 62.6 g (300 mmol) of 6-tert-butyl-2-chloro-5-methylnicotinonitrile, S79, instead of 194.7 g (1 mol) of 2-chloro-3-cyano-6-tert-butylpyridine, S28, and scaling the remaining reagents correspondingly on a molar level. Yield: 68.9 g (271 mmol), 90%. Purity: >95% according to 1H-NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273080B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-06371eb4b0ea4c74a78aa7aba78c49f8 |
| Source note | uspto-grants-2016_03 |