Hydrochloric Acid → HCID 118318816, compound

Participants

Reaction Conditions

Reaction Steps

(2S)-2-(tert-Butoxy)-2-[(20S)-4,16,20,26-tetramethyl-11,19,25-trioxa-1,5,7,8-tetraazapentacyclo[24.2.2.16,9.02,7.013,18]hentriaconta-2,4,6(31),8,13(18),14,16-heptaen-3-yl]acetate (22 mg, 0.035 mmol) was dissolved in MeOH (1 mL). To this was added 1N sodium hydroxide (0.138 mL, 0.138 mmol) and the mixture heated to 60° C. (oil bath temperature). After stirring for 3 hrs the mixture was transferred to a separatory funnel and acidified with 1N HCl. The solution was then extracted with ethyl acetate and the organic layer dried over Na2SO4. After filtration the solvent was removed to under vacuum to provide 24 mg of the title compound as a powder. LCMS (M+H)=609.2.

Provenance & Evidence