反应详情

温度

0 °C

To a mixture of (3-(but-3-en-1-yl)phenyl)methanol (40.2 mg, 0.248 mmol) in DMF (3 mL) at 0° C. was added (S)-ethyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(iodomethyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (145 mg, 0.248 mmol) and NaH (9.92 mg, 0.248 mmol). The mixture was stirred at 0° C. for 3 h. It was then quenched with NH4Cl, extracted with EtOAc. The organic layer was dried over MgSO4, filtered and concentrated. The residue was purified by biotage, eluting with 20% EtOAc/hexane to obtain (S)-ethyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(((3-(but-3-en-1-yl)benzyl)oxy)methyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (50 mg, 0.081 mmol, 32.6% yield) as an oil. LCMS (M+1)=619.5.

1. customIt was then quenched with NH4Cl
2. extractionextracted with EtOAc
3. dry with materialThe organic layer was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by biotage
7. washeluting with 20% EtOAc/hexane