Benzoyl Peroxide → HCID 86713387, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Intermediate 37A (5.5 g, 24.53 mmol), NBS (5.24 g, 29.4 mmol) and benzoyl peroxide (0.594 g, 2.453 mmol) in CCl4 (80 mL) was purged with nitrogen and then heated to 80° C. for 4.5 h. The reaction mixture was cooled to room temperature and then quenched with water. The mixture was extracted with DCM and the combined extracts were washed with saturated NaHCO3 and brine and then dried (Na2SO4), filtered and concentrated to dryness. The crude material was purified by flash chromatography (SiO2, 80 g column, EtOAc/hexane=0-100%) to afford Intermediate 37B.

Provenance & Evidence