HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 5-chloro-N-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| Reactant | (5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxide | HCID 67052694 | — |
| Reactant | 2,5-Dichloro-4-(4-methylpiperazin-1-yl)pyrimidine | HCID 79633391 | — |
| Product | 5-chloro-N-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 68156844 | — |
Reaction Steps
This compound can be prepared by reacting 2,4,5-trichloropyrimidine with 1-Methyl piperazine as described in Example 32 to generate 2,5-dichloro-4-(4-methylpiperazin-1-yl)pyrimidine. 2,5-dichloro-4-(4-methylpiperazin-1-yl)pyrimidine is then reacted with 6-(dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32) as described in Example 32.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273077B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-2edca25be8244ae0ba7f0a4ad90766e7 |
| Source note | uspto-grants-2016_03 |