Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 921341Generated: October 30, 2026

(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxide → N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine

https://huagongshe.com/reaction/921341

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxideHCID 67052694—
Reactant2-Chloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amineHCID 86668791—
ProductN2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamineHCID 68165233—

Reaction Steps

This compound can be prepared as in Example 32 by reacting 2-Chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-pyrimidin-4-amine with 6-(dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09273077B2
Source datasetuspto-grants-2016_03
ORD IDord-be467130babe4f6dba894cb372e0b497
Source noteuspto-grants-2016_03