HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Thienylmethyl)amine → 5-chloro-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]-N2-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Thienylmethyl)amine | HCID 34005 | — |
| Reactant | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| Reactant | 2-Methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)aniline | HCID 67053327 | — |
| Reactant | 2,5-dichloro-N-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidin-4-amine | HCID 86668799 | — |
| Product | 5-chloro-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]-N2-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine | HCID 68157379 | — |
Reaction Steps
The compound can be prepared as in Example 32 by reacting 2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)aniline with 2,4,5-trichloropyrimidine generating 2,5-dichloro-N-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidin-4-amine. 2,5-dichloro-N-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidin-4-amine is then reacted with 1-(thiophen-2-yl)methanamine as described in Example 32.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273077B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-78e68def4c1343c5b73290e57ece6010 |
| Source note | uspto-grants-2016_03 |