5-(Propan-2-yl)-1,3-oxazol-2-amine → 5-chloro-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]-N2-[5-(propan-2-yl)-1,3-oxazol-2-yl]pyrimidine-2,4-diamine

HRID 921349Notes

Reaction equation

HRID 921349 reaction equation
[Cl:1][C:2]1[C:3]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:27][CH2:26][P:25]([CH3:29])(=[O:28])[CH2:24][CH2:23]3)=[CH:18][C:17]=2[O:30][CH3:31])=[N:4][C:5]([NH:8][CH2:9]C2SC=CC=2)=[N:6][CH:7]=1.[CH3:32][CH:33]([C:35]1[O:39]C(N)=[N:37][CH:36]=1)[CH3:34]>>[Cl:1][C:2]1[C:3]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:23][CH2:24][P:25]([CH3:29])(=[O:28])[CH2:26][CH2:27]3)=[CH:18][C:17]=2[O:30][CH3:31])=[N:4][C:5]([NH:8][C:9]2[O:39][C:35]([CH:33]([CH3:34])[CH3:32])=[CH:36][N:37]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 534185155-(Propan-2-yl)-1,3-oxazol-2-amineHCID 681573795-chloro-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]-N2-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine

Product 1

HCID 681652355-chloro-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]-N2-[5-(propan-2-yl)-1,3-oxazol-2-yl]pyrimidine-2,4-diamine

Procedure

The compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidin-4-amine (as described in Example 47) with 5-(propan-2-yl)-1,3-oxazol-2-amine.

Workup

  1. customThe compound can be prepared as in Example 32

Sources & evidence

ORD record
ord-60a19fa46d89435d92f1153eb87408c0
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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