HRID921350

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67053265

未命名化合物

结构：COc1cc(N2CCP(C)(=O)CC2)ccc1Nc1nc(NCc2cccs2)ncc1Cl

HCID68157379

未命名化合物

PRODUCTS

生成物

结构：COc1cc(N2CCP(C)(=O)CC2)ccc1Nc1nc(Nc2ccn(Cc3ccc(F)cc3)c2)ncc1Cl

HCID68157196

未命名化合物

PROCEDURE

实验过程

The compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidin-4-amine (as described in Example 47) with 1-(4-fluorobenzyl)-1H-pyrrol-3-amine.

WORKUP

后处理

customThe compound can be prepared as in Example 32

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-90247580738543aa9c0926a6e31ac379
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09273077B2
来源说明: uspto-grants-2016_03

反应 SMILES

[Cl:1][C:2]1[C:3]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:27][CH2:26][P:25]([CH3:29])(=[O:28])[CH2:24][CH2:23]3)=[CH:18][C:17]=2[O:30][CH3:31])=[N:4][C:5]([NH:8][CH2:9]C2SC=CC=2)=[N:6][CH:7]=1.[F:32][C:33]1[CH:45]=[CH:44][C:36]([CH2:37][N:38]2[CH:42]=C[C:40](N)=[CH:39]2)=[CH:35][CH:34]=1>>[Cl:1][C:2]1[C:3]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:27][CH2:26][P:25]([CH3:29])(=[O:28])[CH2:24][CH2:23]3)=[CH:18][C:17]=2[O:30][CH3:31])=[N:4][C:5]([NH:8][C:9]2[CH:40]=[CH:39][N:38]([CH2:37][C:36]3[CH:35]=[CH:34][C:33]([F:32])=[CH:45][CH:44]=3)[CH:42]=2)=[N:6][CH:7]=1