1-(4-fluorobenzyl)-1H-pyrrol-3-amine → 5-chloro-N2-[1-(4-fluorobenzyl)-1H-pyrrol-3-yl]-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidine-2,4-diamine

HRID 921350Notes

Reaction equation

HRID 921350 reaction equation
[Cl:1][C:2]1[C:3]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:27][CH2:26][P:25]([CH3:29])(=[O:28])[CH2:24][CH2:23]3)=[CH:18][C:17]=2[O:30][CH3:31])=[N:4][C:5]([NH:8][CH2:9]C2SC=CC=2)=[N:6][CH:7]=1.[F:32][C:33]1[CH:45]=[CH:44][C:36]([CH2:37][N:38]2[CH:42]=C[C:40](N)=[CH:39]2)=[CH:35][CH:34]=1>>[Cl:1][C:2]1[C:3]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:27][CH2:26][P:25]([CH3:29])(=[O:28])[CH2:24][CH2:23]3)=[CH:18][C:17]=2[O:30][CH3:31])=[N:4][C:5]([NH:8][C:9]2[CH:40]=[CH:39][N:38]([CH2:37][C:36]3[CH:35]=[CH:34][C:33]([F:32])=[CH:45][CH:44]=3)[CH:42]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 670532651-(4-fluorobenzyl)-1H-pyrrol-3-amineHCID 681573795-chloro-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]-N2-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine

Product 1

HCID 681571965-chloro-N2-[1-(4-fluorobenzyl)-1H-pyrrol-3-yl]-N4-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidine-2,4-diamine

Procedure

The compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-[2-methoxy-4-(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)phenyl]pyrimidin-4-amine (as described in Example 47) with 1-(4-fluorobenzyl)-1H-pyrrol-3-amine.

Workup

  1. customThe compound can be prepared as in Example 32

Sources & evidence

ORD record
ord-90247580738543aa9c0926a6e31ac379
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

Loading…