HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[5-(4-Methylpiperazin-1-yl)-1,3,4-oxadiazol-2-yl]methanamine → 5-chloro-N4-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-N2-{[5-(4-methylpiperazin-1-yl)-1,3,4-oxadiazol-2-yl]methyl}pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[5-(4-Methylpiperazin-1-yl)-1,3,4-oxadiazol-2-yl]methanamine | HCID 24255092 | — |
| Reactant | N2-[5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-yl]-5-chloro-N4-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]pyrimidine-2,4-diamine | HCID 68165236 | — |
| Product | 5-chloro-N4-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]-N2-{[5-(4-methylpiperazin-1-yl)-1,3,4-oxadiazol-2-yl]methyl}pyrimidine-2,4-diamine | HCID 68157098 | — |
Reaction Steps
This compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-[5-(dimethylphosphoryl)-3-methoxypyrazin-2-yl]pyrimidin-4-amine (as described in Example 51) with 1-[5-(4-methylpiperazin-1-yl)-1,3,4-oxadiazol-2-yl]methanamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273077B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-0b9eabe3438d478ab6580d17621b87d6 |
| Source note | uspto-grants-2016_03 |