4,6-Dichloropyrimidine → 6-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine

Participants

Reaction Steps

A suspension of 4-amino-dimethylphenylphosphine oxide (2.2 mmol) in 15 mL of N,N-Dimethylformamide and 3.6 mL of Diisopropylethylamine, is stirred at room temperature until a clear solution is obtained. 4,6-Dichloropyrimidine (2.6 mmol) is added in four portions over 5 minutes. The reaction mixture is stirred at high temperature until formation of the desired compound.

Provenance & Evidence