HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[4-(dimethylphosphoryl)-2-methoxyphenyl]-2-methyl-N'-phenylpyrimidine-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-chloro-2-methyl-N-phenylpyrimidin-4-amine | HCID 45071764 | — |
| Reactant | (4-Amino-3-methoxyphenyl)dimethylphosphine oxide | HCID 67052699 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[4-(dimethylphosphoryl)-2-methoxyphenyl]-2-methyl-N'-phenylpyrimidine-4,6-diamine | HCID 67052691 | — |
Reaction Steps
To a solution of 6-chloro-2-methyl-N-phenylpyrimidin-4-amine (0.35 mmol) and 4-(dimethylphosphoryl)-2-methoxyaniline (60 mg, 0.30 mmol) in 1 mL of DMF, is added 0.36 mL of 2.5M HCl in Ethanol. The reaction mixture can be heated in a sealed tube at 140 degrees until formation of the desired compound. The reaction mixture is filtered through a syringe filter and can be purified by Prep-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273077B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-61792d56440a45a3bc3781c03caf8dd4 |
| Source note | uspto-grants-2016_03 |