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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 921400Generated: October 31, 2026

4-(Dimethylphosphoryl)-2-(trifluoromethoxy)aniline → N2-[4-(dimethylphosphoryl)-2-(trifluoromethoxy)phenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamine

https://huagongshe.com/reaction/921400

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Dimethylphosphoryl)-2-(trifluoromethoxy)anilineHCID 67052684—
Reactant2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amineHCID 86668814—
ProductN2-[4-(dimethylphosphoryl)-2-(trifluoromethoxy)phenyl]-N4-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridine-2,4-diamineHCID 86668815—

Reaction Steps

This compound can be prepared as described in Example 80 by reacting 2-chloro-N-[2-(propan-2-ylsulfonyl)phenyl]-5-(trifluoromethyl)pyridin-4-amine with 4-(Dimethylphosphoryl)-2-(trifluoromethoxy)aniline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09273077B2
Source datasetuspto-grants-2016_03
ORD IDord-3dbccbe846c44413a3cbf35c0c201961
Source noteuspto-grants-2016_03