HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 921415Generated: October 27, 2026
Potassium Carbonate → 1-(3-Methoxy-4-nitrophenyl)-4-methyl-1,4-azaphosphinane 4-oxide
https://huagongshe.com/reaction/921415
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Fluoro-2-nitroanisole | HCID 2779250 | — |
| Reactant | 4-Methyl-1,4lambda5-azaphosphinan-4-one | HCID 55298899 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-Methoxy-4-nitrophenyl)-4-methyl-1,4-azaphosphinane 4-oxide | HCID 68156988 | 96% |
Reaction Steps
A mixture of 4-methyl-[1,4]azaphosphinane-4-oxide (133 mg, 1.00 mmol), 5-fluoro-2-nitroanisole (340 mg, 2.00 mmol), K2CO3 (345 mg, 2.50 mmol), and DMF (5 mL) was heated to 50° C. After 2 h, the reaction mixture was concentrated and purified by silica gel chromatography (0-5% 7N ammonia in methanol:dichloromethane) to afford 1-(3-methoxy-4-nitrophenyl)-4-methyl-1,4-azaphosphinane 4-oxide as a bright yellow solid (272 mg, 96% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273077B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-e393424610ab4fddb70d303e5d3a6fbb |
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| Source note | uspto-grants-2016_03 |
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