Amantadine → N-[4-(dimethylphosphoryl)phenyl]-N'-(tricyclo[3.3.1.13,7]dec-1-yl)-1,3,5-triazine-2,4-diamine

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Reaction Steps

To a solution of 4-chloro-N-[4-(dimethylphosphoryl)phenyl]-1,3,5-triazin-2-amine (prepared as in Example 92: 0.078 mmol) in 1.5 mL of ethanol is added 10 L of triethylamine and 1-Adamantanamine (12 mg, 0.078 mmol). The mixture can be microwaved at 120 degrees until formation of the desired compound. The reaction mixture is filtered through a syringe filter and purified by prep-HPLC.

Provenance & Evidence