HCID 67052695, compound → HCID 67052708, compound

HRID 921450Notes

Reaction equation

HRID 921450 reaction equation
[CH3:1][P:2](=[O:19])([CH3:18])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[C:5]([S:12]([CH:15]([CH3:17])[CH3:16])(=[O:14])=[O:13])[CH:4]=1>C(O)C.[Pd]>[CH3:18][P:2]([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([S:12]([CH:15]([CH3:17])[CH3:16])(=[O:14])=[O:13])[CH:4]=1)([CH3:1])=[O:19]

Participants

4

Reactant 1

HCID 67052695HCID 67052695, compound

Product 1

HCID 67052708HCID 67052708, compoundYield 50%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of dimethyl[4-nitro-3-(propan-2-ylsulfonyl)phenyl]phosphane oxide (0.24 g, 0.88 mmol) in Ethanol was added Pd on carbon (10% w/w, 24 mg) and stirred under hydrogen overnight. The reaction mixture was filtered and the organic solvent was removed under reduced pressure. The residue was purified by prep-HPLC to yield 100 mg of desired product (50% yield).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe organic solvent was removed under reduced pressure
  3. customThe residue was purified by prep-HPLC

Sources & evidence

ORD record
ord-dd46ab526636405da5730c60b3f896d7
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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