反应详情

A solution of methyl divinyl phosphine oxide (140 mg, 1.21 mmol) and 1-Boc-4-aminopiperidine (265 mg, 1.33 mmol) in 1:1 THF/water (3 mL) was heated at reflux for 16 h. The reaction mixture was concentrated in vacuo and the residue was purified by silica gel chromatography (0-10% 7N ammonia in methanol:dichloromethane) to afford the desired compound as a white solid (178 mg, 38% yield).

1. temperatureat reflux for 16 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. customthe residue was purified by silica gel chromatography (0-10% 7N ammonia in methanol:dichloromethane)