HCID 14245847, compound → HCID 428467, compound

HRID 921511Notes

Reaction equation

HRID 921511 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH:7]([NH:9][CH2:10][C:11]([CH3:17])([CH3:16])[CH2:12][NH:13][CH:14]=O)=O>CCOCC>[CH3:7][NH:9][CH2:10][C:11]([CH3:17])([CH3:16])[CH2:12][NH:13][CH3:14]

Participants

4

Reactant 2

HCID 14245847HCID 14245847, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 428467HCID 428467, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a mixture of 250 mL of ether and 10 g of LiAlH4 (95%) at 0° C., 9.88 g (62.5 mmol) N,N′-diformyl-2,2-dimethylpropane-1,3-diamine was added in small portions. After the addition, the reaction mixture was stirred at room temperature for 20 h. The mixture was then hydrolyzed with ether and water, the white solid removed by filtration through Celite, and the filtrate dried over anhydrous Na2SO4. After removal of the solvent, the product was obtained as a colorless oil. MS (m/e): 131 (M+).

Workup

  1. additionAfter the addition
  2. customhydrolyzed with ether and water, the white solid removed by filtration through Celite
  3. dry with materialthe filtrate dried over anhydrous Na2SO4
  4. customAfter removal of the solvent
  5. customthe product was obtained as a colorless oil

Sources & evidence

ORD record
ord-cf41ee942e22437eb95d69e2f78610fb
Source dataset
uspto-grants-2016_03
Patent number
US09273343B2

Reaction notes

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