HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → 6-((tert-Butoxycarbonyl)amino)hexyl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-Butyl N-(6-hydroxyhexyl)carbamate | HCID 4146612 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-((tert-Butoxycarbonyl)amino)hexyl methanesulfonate | HCID 18465478 | — |
Reaction Steps
To a solution of tert-butyl (6-hydroxyhexyl)carbamate (12.18 g, 56.05 mmol) and TEA (8.51 g, 84.08 mmol) in 100 ml of methylene chloride, methanesulfonyl chloride (9.63 g, 84.08 mmol) was slowly added at 0° C. The mixture was stirred at room temperature overnight. The compound was purified by silica chromatography using heptane/ethyl acetate as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273343B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-d7d7465185164485b38305dc189586c5 |
| Source note | uspto-grants-2016_03 |