Benzoic acid, 4-hydroxy-3-nitro-, methyl ester → Methyl 3-bromo-4-hydroxy-5-nitrobenzoate

Participants

Reaction Steps

(I4A): Methyl 4-hydroxy-3-nitrobenzoate (15 g, 76 mmol) was suspended in acetic acid (152 ml) and then treated with NBS (20.31 g, 114 mmol). The mixture became a homogeneous yellow solution which was stirred for 2 h. The mixture was quenched with water and the suspension was filtered. Methyl 3-bromo-4-hydroxy-5-nitrobenzoate (20 g) was obtained as a yellow solid.

Provenance & Evidence