HRID921648

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6115

Aniline

C6H7N

结构：COc1ccc(CN(c2nc(S(C)(=O)=O)nn3c(C#N)cnc23)C2CC2)cc1

HCID86708519

未命名化合物

结构：COC(=O)N[C@H]1CCN(c2cc(C#N)cc(N)c2Cl)C[C@@H]1O[Si](C)(C)C(C)(C)C

HCID89919054

未命名化合物

PRODUCTS

生成物

结构：COC(=O)N[C@H]1CCN(c2cc(C#N)cc(Nc3nc(N(Cc4ccc(OC)cc4)C4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@@H]1O[Si](C)(C)C(C)(C)C

HCID131732380

未命名化合物

PROCEDURE

实验过程

methyl ((3S,4S)-3-((tert-butyldimethylsilyl)oxy)-1-(2-chloro-5-cyano-3-((7-cyano-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperidin-4-yl)carbamate was prepared starting from methyl ((3S,4S)-1-(3-amino-2-chloro-5-cyanophenyl)-3-((tert-butyldimethylsilyl)oxy) piperidin-4-yl)carbamate (127 mg, 0.289 mmol) according to general procedure for the coupling of aniline to 4-(cyclopropyl(4-methoxybenzyl)amino)-2-(methylsulfonyl)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile, method described for Example 7. Methyl ((3S,4S)-3-((tert-butyldimethylsilyl)oxy)-1-(2-chloro-5-cyano-3-((7-cyano-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperidin-4-yl)carbamate (180 mg) was obtained as a white solid.

WORKUP

后处理

custommethyl ((3S,4S)-3-((tert-butyldimethylsilyl)oxy)-1-(2-chloro-5-cyano-3-((7-cyano-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperidin-4-yl)carbamate was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-91d73e75a4994cef995ad238897aef6a
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09273057B2
来源说明: uspto-grants-2016_03

反应 SMILES

[NH2:1][C:2]1[C:3]([Cl:29])=[C:4]([N:10]2[CH2:15][CH2:14][C@H:13]([NH:16][C:17](=[O:20])[O:18][CH3:19])[C@@H:12]([O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH2:11]2)[CH:5]=[C:6]([C:8]#[N:9])[CH:7]=1.NC1C=CC=CC=1.[CH:37]1([N:40]([CH2:56][C:57]2[CH:62]=[CH:61][C:60]([O:63][CH3:64])=[CH:59][CH:58]=2)[C:41]2[C:46]3=[N:47][CH:48]=[C:49]([C:50]#[N:51])[N:45]3[N:44]=[C:43](S(C)(=O)=O)[N:42]=2)[CH2:39][CH2:38]1>>[Si:22]([O:21][C@@H:12]1[C@@H:13]([NH:16][C:17](=[O:20])[O:18][CH3:19])[CH2:14][CH2:15][N:10]([C:4]2[CH:5]=[C:6]([C:8]#[N:9])[CH:7]=[C:2]([NH:1][C:43]3[N:42]=[C:41]([N:40]([CH:37]4[CH2:39][CH2:38]4)[CH2:56][C:57]4[CH:62]=[CH:61][C:60]([O:63][CH3:64])=[CH:59][CH:58]=4)[C:46]4=[N:47][CH:48]=[C:49]([C:50]#[N:51])[N:45]4[N:44]=3)[C:3]=2[Cl:29])[CH2:11]1)([C:25]([CH3:26])([CH3:28])[CH3:27])([CH3:23])[CH3:24]