HRID921701

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31297

Methanesulfonyl chloride

CH3ClO2S

结构：N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(C2CCN(C3CNC3)CC2)c1

HCID86708575

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)N1CC(N2CCC(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C1

HCID86708577

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 2-((3-(1-(azetidin-3-yl)piperidin-4-yl)-2-chloro-5-cyanophenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (Example 318) and methanesulfonyl chloride using a method analogous to that used to prepare Example 319 HPLC Rt 3.020 min

WORKUP

后处理

customto prepare Example 319 HPLC Rt 3.020 min

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-972c8ed2f41b4b51b386b7d74e78e5d8
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09273057B2
来源说明: uspto-grants-2016_03

反应 SMILES

[NH:1]1[CH2:4][CH:3]([N:5]2[CH2:10][CH2:9][CH:8]([C:11]3[C:12]([Cl:35])=[C:13]([NH:19][C:20]4[N:25]=[C:24]([NH:26][CH:27]5[CH2:29][CH2:28]5)[C:23]5=[N:30][CH:31]=[C:32]([C:33]#[N:34])[N:22]5[N:21]=4)[CH:14]=[C:15]([C:17]#[N:18])[CH:16]=3)[CH2:7][CH2:6]2)[CH2:2]1.[CH3:36][S:37](Cl)(=[O:39])=[O:38]>>[Cl:35][C:12]1[C:11]([CH:8]2[CH2:7][CH2:6][N:5]([CH:3]3[CH2:2][N:1]([S:37]([CH3:36])(=[O:39])=[O:38])[CH2:4]3)[CH2:10][CH2:9]2)=[CH:16][C:15]([C:17]#[N:18])=[CH:14][C:13]=1[NH:19][C:20]1[N:25]=[C:24]([NH:26][CH:27]2[CH2:28][CH2:29]2)[C:23]2=[N:30][CH:31]=[C:32]([C:33]#[N:34])[N:22]2[N:21]=1