Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

tert-butyl 4-(3-amino-2-fluoro-5-((4-methoxybenzyl)(methoxycarbonyl)amino)phenyl)piperazine-1-carboxylate (317 mg, 0.474 mmol) was dissolved in ClCH2CH2Cl (4 ml). Trifluoroacetic acid (1 ml, 12.98 mmol) was added and the reaction mixture was stirred at room temperature for 2 hours, and then evaporated to dryness. 470.1 mg crude methyl (3-amino-4-fluoro-5-(piperazin-1-yl)phenyl)(4-methoxybenzyl)carbamate, TFA (470.1 mg) were isolated. The material was used for a next step

Provenance & Evidence