HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoro-5-nitrobenzonitrile → 5-Amino-2,4-difluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoro-5-nitrobenzonitrile | HCID 11819715 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-2,4-difluorobenzonitrile | HCID 66848406 | 70.5% |
Reaction Steps
A suspension of 2,4-difluoro-5-nitrobenzonitrile (1.0 g, 5.43 mmol) and Pd/C 10% (0.1 g, 0.94 mmol) in MeOH (20 mL) was hydrogenated (balloon) for 5 hr. This was filtered and the solvent was removed. Flash chromatography on silica gel eluting with hexane containing 20% EtOAc gave 5-amino-2,4-difluorobenzonitrile (0.59 g) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273057B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-3bd5255189934367b37a35f73a949d36 |
| Source note | uspto-grants-2016_03 |