Triacetoxyperiodinane → HCID 89922850, compound

Participants

Reaction Conditions

Reaction Steps

2-((2-chloro-5-cyano-4-(4-hydroxybutyl)phenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (186 mg, 0.343 mmol) was taken up in DCM (3 mL) and cooled to 0° C. Dess-Martin periodinane (189 mg, 0.445 mmol) was added, and the reaction was stirred at room temperature for 1.5 h. The reaction mixture was quenched with 2M K3PO4 solution and extracted 2× with DCM. The organic layers were combined, dried over Na2SO4, filtered, and concentrated. The material was purified by flash column chromatography (0-60% EtOAc/IIex; 40 g column). 2-((2-chloro-5-cyano-4-(4-oxobutyl)phenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (135 mg) was obtained as a yellow glass.

Provenance & Evidence