HCID 131734939, compound → HCID 131734938, compound

Participants

Reaction Steps

Tert-butyl (2-chloro-5-cyano-3-(3-hydroxyprop-1-en-2-yl)phenyl)carbamate (161 mg, 0.521 mmol) was taken up in EtOH (3 mL) and the solution was purged with N2. Next, Pd/C (55.5 mg, 0.052 mmol) was added and the solution was again evacuated and purged with N2 3×. Next, a balloon with H2 was added, and the reaction was stirred for 1 h. The reaction mixture was filtered through celite, rinsing with MeOH. The solvent was removed in vacuo and the material was purified by flash column chromatography (0-50% EtOAc/Hex; 40 g column). Tert-butyl (2-chloro-5-cyano-3-(1-hydroxypropan-2-yl)phenyl)carbamate (36 mg) was obtained as a colorless glass.

Provenance & Evidence