Trifluoroacetic acid → HCID 89923297, compound

Participants

Reaction Steps

To a solution of racemic tert-butyl (2-chloro-5-cyano-3-(8-methyl-9-oxohexahydro-1H-pyrazino[1,2-a]pyrazin-2(6H)-yl)phenyl)carbamate (60 mg, 0.143 mmol) in DCM (1.5 mL) was added 1 mL of TFA. After stirring for 1 h, LC-MS indicated completion. It was concentrated and purification via flash chromatography (0-5% MeOH in DCM, 12 g) gave racemic 3-amino-4-chloro-5-(8-methyl-9-oxohexahydro-1H-pyrazino[1,2-a]pyrazin-2(6H)-yl)benzonitrile (35 mg, 0.109 mmol, 77% yield) as a yellow solid.

Provenance & Evidence