Trifluoroacetic acid → HCID 89923004, compound

Participants

Reaction Steps

A solution of 2-((2-chloro-5-cyano-3-(prop-1-en-2-yl)phenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (748 mg, 1.46 mmol) and anisole (4.00 mL, 36.6 mmol) in DCM (23 mL) and TFA (23 mL, 290 mmol) was left stirring at room temperature overnight. The solvents were removed and the yellow solid was suspended in DCM. This was washed with saturated aq. NaHCO3 solution and dried with sodium sulfate. The solvent was removed and the residue was suspended in a mixture of EtOAc: hexane=1:1. This was filtered to give 2-((2-chloro-5-cyano-3-(prop-1-en-2-yl)phenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (365 mg) as a light yellow solid.

Provenance & Evidence