Piperazin-2-one → HCID 89934249, compound

HRID 921899Notes

Reaction equation

HRID 921899 reaction equation
CS(O[CH:6]([C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[C:10]([NH:16][C:17]2[N:22]=[C:21]([NH:23][CH:24]3[CH2:26][CH2:25]3)[C:20]3=[N:27][CH:28]=[C:29]([C:30]#[N:31])[N:19]3[N:18]=2)[C:9]=1[Cl:32])[CH3:7])(=O)=O.[NH:33]1[CH2:38][CH2:37][NH:36][CH2:35][C:34]1=[O:39]>>[Cl:32][C:9]1[C:8]([CH:6]([N:36]2[CH2:37][CH2:38][NH:33][C:34](=[O:39])[CH2:35]2)[CH3:7])=[CH:13][C:12]([C:14]#[N:15])=[CH:11][C:10]=1[NH:16][C:17]1[N:22]=[C:21]([NH:23][CH:24]2[CH2:25][CH2:26]2)[C:20]2=[N:27][CH:28]=[C:29]([C:30]#[N:31])[N:19]2[N:18]=1

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 89922440HCID 89922440, compound

Product 1

HCID 89934249HCID 89934249, compound

Procedure

This was similarly prepared as Example 678 from 1-(2-chloro-5-cyano-3-((7-cyano-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)ethyl methanesulfonate and piperazin-2-one (22.74 mg).

Sources & evidence

ORD record
ord-71250d7b74324bf09abf3a298f46cb42
Source dataset
uspto-grants-2016_03
Patent number
US09273057B2

Reaction notes

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