HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 921913Generated: October 28, 2026
Ethyl isocyanate → HCID 89923215, compound
https://huagongshe.com/reaction/921913
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | (+/-)-2-((2-Chloro-5-cyano-3-(2-(hydroxymethyl)morpholino)phenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | HCID 89922871 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 89923215 | HCID 89923215 | — |
Reaction Steps
To a vial was charged with 2-((2-chloro-5-cyano-3-(2-(hydroxymethyl)morpholino)phenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (Example 1) (30 mg, 0.051 mmol) in tetrahydrofuran (256 μl) was added ethyl isocyanate (4.86 μl, 0.061 mmol). The vial was capped and heated at 50° C. over the weekend. Reaction temperature was raised to 70° C. for 6 h to get full conversion. Solvent was removed in vacuo and the crude residue was taken forward as is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273057B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-efb7d438c8bf4aa6bb0e5edcc0610850 |
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| Source note | uspto-grants-2016_03 |
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