Methyl iodide → HCID 89922761, compound

Participants

Reaction Steps

A vial was charged with 2-((2-chloro-5-cyano-3-(4-((1-methyl-5-oxopyrrolidin-3-yl)amino)piperidin-1-yl)phenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (35 mg, 0.053 mmol) and iodomethane (3.94 μl, 0.063 mmol) in tetrahydrofuran (263 μl). Cesium carbonate (34.2 mg, 0.105 mmol) was added and the reaction mixture was stirred at room temperature 5 h. The reaction mixture was quenched with water and ethyl acetate. The aqueous layer was extracted with ethyl acetate (2×). The combined organics were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude material was used as is in the final deprotection.

Provenance & Evidence