Dicyclohexylcarbodiimide → HCID 178463452, compound

Participants

Reaction Steps

To a solution of (Example 328) methyl ((3R,4R)-1-(2-chloro-5-cyano-3-((7-cyano-4-(ethylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)-3-hydroxypiperidin-4-yl)carbamate (50 mg, 0.098 mmol), BOC-ARG(BOC)2-OH (96 mg, 0.202 mmol), DMAP (2.391 mg, 0.020 mmol) and DCC (60.6 mg, 0.294 mmol) were dissolved in DCM (5 mL) under nitrogen. The reaction mixture was stirred at room temperature 12 hr; the LCMS showed complete conversion. The solvent was removed and the material was diluted with acetone and filtered (removes 1,3-dicyclohexylurea).

Provenance & Evidence