Acetic Acid → HCID 89934139, compound

Participants

Reaction Steps

(+/−)-2-((3-((3R,4R)-4-amino-3-hydroxypiperidin-1-yl)-2-chloro-5-cyanophenyl)amino)-4-(ethylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (80 mg, 0.177 mmol) was taken up in MeOH (1.0 mL) and DMF (1.0 mL) and trimethyl orthoformate (1.464 mL, 13.25 mmol), AcOH (0.040 mL, 0.707 mmol), and oxetan-3-one (0.113 mL, 1.766 mmol) were added. The reaction was stirred at room temperature for 2 h, then NaCNBII3 (111 mg, 1.766 mmol) was added and the reaction stirred at 25° C. overnight.

Provenance & Evidence