Water → HCID 89923005, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3R,4R)-methyl 3-hydroxy-4-((E)-(4-methoxybenzylidene)amino)piperidine-1-carboxylate (499 mg, 1.707 mmol) in MeOH (17 ml) was added water (1 ml, 55.5 mmol) and TFA (2 ml, 26.0 mmol). The reaction was stirred at 50° C. overnight. The reaction mixture was applied on a SCX column (Phenomenex, Strata XC) and eluted with 2N ammonia in methanol. The solvents removed to afford (3R,4R)-methyl 4-amino-3-hydroxypiperidine-1-carboxylate (290 mg).

Provenance & Evidence