Methanol → 3,5-dimethyldodecanoic acid

Temperature

65 °C

In a nitrogen atmosphere, the crude product (1.22 g, 0.00452 mol) of ethyl 3,5-dimethyldodecanoate (7Et) produced in the method of Example 3-1, methanol (1 ml), a 25% by weight aqueous sodium hydroxide solution (3 ml) were placed in a reaction vessel and stirred at 65° C. for 2 hours. After addition of water, the resulting mixture was washed with a hexane-tetrahydrofuran mixture. The aqueous phase was made acidic in addition of 20% by weight hydrochloric acid, followed by extraction with a hexane-tetrahydrofuran mixture. The organic phase thus obtained was dried over magnesium sulfate and then concentrated under reduced pressure. The concentrate thus obtained was distilled under reduced pressure (bp: from 130 to 140° C./2 mmHg) to obtain 3,5-dimethyldodecanoic acid (5) (1.03 g, 0.00452 mol). A total yield of the three steps from the 2-methylnonyl chloride (1 Cl) was 60%.

1. washthe resulting mixture was washed with a hexane-tetrahydrofuran mixture
2. additionThe aqueous phase was made acidic in addition of 20% by weight hydrochloric acid
3. extractionfollowed by extraction with a hexane-tetrahydrofuran mixture
4. customThe organic phase thus obtained
5. dry with materialwas dried over magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. concentrationThe concentrate thus
8. customobtained
9. distillationwas distilled under reduced pressure (bp: from 130 to 140° C./2 mmHg)

ORD record

ord-60eb53bc4fa44b61ac5f47e4ce7f8a08

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09278900B2