HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 922113Generated: October 28, 2026
Thionyl Chloride → (5-Bromo-2-methylphenyl)acetyl chloride
https://huagongshe.com/reaction/922113
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(5-Bromo-2-methylphenyl)acetic acid | HCID 51063743 | — |
| Product | (5-Bromo-2-methylphenyl)acetyl chloride | HCID 51063875 | — |
Reaction Steps
6.00 g (26.19 mmol) of (5-bromo-2-methylphenyl)acetic acid (EP 1791816 A1 and US 2006/29799 A1) were dissolved in 31.20 g (261.92 mmol) of thionyl chloride. The reaction mixture was stirred at 80° C. for two hours and then concentrated under reduced pressure. Drying under fine vacuum gave 6.29 g (97% of theory) of the title compound as a brownish oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09278925B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-14eaf8157f754a88a4b404003c280d14 |
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| Source note | uspto-grants-2016_03 |
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