Thionyl Chloride → (4'-Chloro-3'-fluoro-4-methylbiphenyl-3-yl)acetyl chloride

Participants

Reaction Conditions

Reaction Steps

10.00 g (35.88 mmol) of (4′-chloro-3′-fluoro-4-methylbiphenyl-3-yl)acetic acid (Example 1A) were dissolved in 24.33 g (204.51 mmol) of thionyl chloride. The reaction mixture was stirred at 80° C. for one hour and then concentrated under reduced pressure. Drying under fine vacuum gave 10.54 g (99% of theory) of the title compound as a brownish oil.

Provenance & Evidence